Collagenases for Tissue Dissociation

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Concentration of collagenases (MMP-1, -8, -13) in patients with chronically inflamed dental pulp tissue.

Matrix metalloproteinases (MMPs) form an enzyme family capable of degrading almost all extracellular matrix (ECM) and basement membrane (BM) components. They play an important role in normal tissue remodelling and growth, as well as in many destructive pathological conditions such as inflammation, tumour growth and metastasis. The role of MMPs in the breakdown of pulp tissue of teeth with pulpi...

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Tumor cell motility and the passage of tumor cells through various tissue matrices, including basement membrane, are important components of the metastatic process. Proteolytic enzymes, including a type IV collagen-specific collagi-nasi-, have been demonstrated to play a signifi cant role in extracellular matrix and basement membrane degradation. In addition, exogenous collagenase has been show...

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Directed migration of murine and human tumor cells to collagenases and other proteases.

Tumor cell motility and the passage of tumor cells through various tissue matrices, including basement membrane, are important components of the metastatic process. Proteolytic enzymes, including a type IV collagen-specific collagenase, have been demonstrated to play a significant role in extracellular matrix and basement membrane degradation. In addition, exogenous collagenase has been shown t...

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Directed Migration of Murine and Human Tumor Cells to Collagenases and Other Proteases1

Tumor cell motility and the passage of tumor cells through various tissue matrices, including basement membrane, are important components of the metastatic process. Proteolytic enzymes, including a type IV collagen-specific collagi-nasi-, have been demonstrated to play a signifi cant role in extracellular matrix and basement membrane degradation. In addition, exogenous collagenase has been show...

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Matrix Metalloproteinase Levels in Chronic Periapical Lesions and Inflamed Dental Pulps

The aim of this study was to accomplish quantitative measurement of tissue levels of collagenases (MMP-1, 8 and 13) in chronic inflamed tissues (pulp and periapical lesions), as well as to determine the dependence between collagenase level and the degree of tissue destruction of examined material. Chronic periapical tissues were collected by periapical surgery from 50 teeth with clinically and ...

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تاریخ انتشار 2008